Nattobiotic

Arthur Andrew Medical





Nattobiotic has been replaced by our newest product Nattovena. Please read the letter from our CEO below explaining the reasons for this change. To purchase our New product, please CLICK HERE to visit the Nattovena purchase page.

7/25/2013

Re: Nattobiotic

From Justin Andrew Marsh, CEO of Arthur Andrew Medical

To all of our valued customer and clientele:

With great regret we are writing to inform you that we are discontinuing the manufacture of our raw nattokinase product, Nattobiotic. My team and I at Arthur Andrew Medical take great pride in offering unique and efficacious products to the market. Unfortunately, with unique and forward-thinking products comes risk, as there are typically not readily available materials that can replace such products in the event of shortages. Nattobiotic possesses unique qualities that cannot simply be duplicated by combining various available components due to the fact that it is a raw food sourced extract (believe me, we tried!).

As you may or may not know, we have endured a lengthy shortage of Nattobiotic over the past several months while we worked to procure the base material used in the formula. Because the product is a food sourced extract, there are always variables in nature that can impact the manufacturing process and the resulting product. These variables are what caused the significant delays in production of the product. Unfortunately, our efforts have only resulted in a material that continues to not meet our stringent demands for activity levels and quality that we set when we released the product in 2011.

Due to these inconsistencies delaying our production process, we have decided that it is in the best interest for us and our clientele to forego manufacturing and promoting the product as we cannot guarantee a consistent stock, and we likely would not have additional inventory for months. We are still holding out hope that we can refine the process that provided us the unique material we brought to the market in our previous batches… but until then, we will be replacing the formula with a nattokinase product that we can stand behind, which will also be a great value to our clients.

With that said, I am pleased to announce the arrival of Nattovena (Na-toe-vay-na), a pure nattokinase which will boast 4,000 fibrinolytic units per capsule, making it the industry’s strongest and most potent nattokinase product available. What makes the release of Nattovena even more exciting is that we have been able to competitively price this product at an unprecedentedly low price. Nattovena will be more affordable than many of the leading brands that contain half, or even a fourth, of the activity of Nattovena.

Nattovena will be offered in 30, 90, and 180 capsule count bottles. For information on pricing and opening order discounts, please contact us at 800-448-5015. We look forward to the rollout of this new and exciting product which we anticipate to be ready for release by September 20th.

I personally thank you all for your loyalty and patronage to Arthur Andrew Medical. My staff and I look forward to continue to serve you with only the best in quality and efficacious products.

Thank you sincerely,

Justin A Marsh

CEO


Nattobiotic is the world's first raw nattokinase dietary supplement, as well as the first and only raw nattokinase synbiotic.*

Nattobiotic contains raw natto, including its naturally occurring antioxidants, vitamin K2, 10 essential amino acids and nattokinase-producing probiotic Bacillus subtilis plus an added prebiotic, Isomalto-Oligosacharide.*

Nattobiotic is specifically formulated to address fibrin imbalances in the body. Fibrin is a protein that plays a major role in normal blood viscosity and scar formation, making it an essential component of the healing process and vital for maintaining our health and general well being.* However, fibrin overproduction and impaired fibrin clearance has been implicated in many of today's most common health concerns, including cardiovascular health, lung function, cognitive health, immune, skin and breast and uterine health.*


Benefits of Raw Nattokinase

Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme derived from a Japanese fermented soybean food called natto [1-4]. These soybeans are fermented with the Bacillus subtilis bacteria [3,4] which produces an enzyme called nattokinase.* The resulting food, natto, has a very slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have a number of health benefits.* For its use in nutritional supplements, the nattokinase enzyme is typically extracted and purified in a laboratory setting.*

Natto has been involved in numerous studies, and the results show that it has the most potent oral fibrinolytic activity of over 200 foods tested [6]*. Nattobiotic's unique formula boosts the powerful fibrinolytic activity of nattokinase by utilizing the benefits of raw natto food rather than a nattokinase enzyme extract.* Raw natto inherently contains vitamins, minerals, antioxidants and probiotics that are generally removed during the nattokinase extraction process.* These important co-factors make the fibrinolytic enzymes more bioavailable in the body, increasing their effectiveness and impact.*

Nattobiotic not only contains nattokinase but also the live probiotics, antioxidants, nutrients and other enzymes created during the fermentation process.* This gives Nattobiotic's exclusive synbiotic formula the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, allowing it to hydrolyze 5,000 units of fibrin per dose (2 capsules), and optimizes its health benefits.*

Nattokinase & Fibrinolysis

Fibrin is naturally produced in the body by a protein called thrombin and is degraded by a protein called plasmin.* Usually these processes exist in a delicate balance; however, as we age, fibrinolysis is impaired and fibrin begins to accumulate in the body.* Nattokinase supplementation, however, can tip the balance back in favor of fibrin removal using two different mechanisms.*

Firstly, nattokinase is a naturally fibrinolytic enzyme, which means that it can support the body's ability to produce normal amounts of fibrin [2]*. In fact, nattokinase is actually 4-times more potent than the body's own natural fibrin degrading enzyme, plasmin*[7].

Nattokinase has also has been shown to support normal levels of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrinolytic capabilities even more [8,9].* High levels of PAI-1 are directly linked to impaired fibrin degradation and removal because PAI-1 blocks the body's natural production of plasmin* [10]. By supporting normal amounts of PAI-1, nattokinase promotes the conversion of more plasminogen into plasmin, increasing the amount of fibrinolytic proteins in the blood.*

Vitamin K2 (The forgotten Vitamin)

According to the Rotterdam researchers, higher vitamin K2 intake has been shown to help regulate calcification of your tissues [21]*. Tissue calcification plays a significant role in influencing optimal cardiovascular health.* Vitamin K has been shown to support normal calcification of your tissues by providing the proper calcium pathway from your blood to your bones.*

Vitamin K2 may also exert cardio-protective effects by supporting normal blood clotting near the inner surface of the blood vessel walls [21]*. Vitamin K is essential for the functioning of several proteins involved in blood clotting [25], which is why it is the target for anticoagulant drugs like warfarin.* However, according to Dutch Professor Cees Vermeer, vitamin K2 helps promote normal clot formation when blood vessels are intact and promote normal clotting when blood vessels are broken, thereby regulating the body's natural clotting factor mechanisms.* As a result, inhibiting vitamin K2 may actually be detrimental to vascular health.*

Synbiotic Benefits

Each Nattobiotic capsule contains 1 billion colony-forming units (CFUs) of probiotic B. subtilis, as well as a prebiotic fiber, Isomalto-Oligosacharide. This mixture of pro- and prebiotics is known as a synbiotic [31]*.

Bacillus Subtilis

Probiotics are "good" bacteria that boost health when taken orally and are allowed to grow and multiply in the body [32]*. B. subtilis is especially suited for growing in and colonizing the gastrointestinal tract because it is a spore-forming bacteria.* Most bacteria are destroyed by the acidic pH range, mainly thriving in the more alkaline lower GI tract, but spores are able to withstand a broader range of pH and temperature [33,34]*. This improves the chances that the probiotic strain will be able to thrive in the GI tract.*

Research has shown that natto intake can increase the number of B. subtilis in the gut, as well as affect the metabolic activity of the intestinal microflora [35,36]*. This is because once they are established in the small intestine, B. subtilis probiotics act like tiny factories, producing beneficial vitamins (like vitamin K2), minerals, antioxidants and enzymes (like nattokinase) that help support and maintain digestive and overall good health [37].*

In one clinical study, 80 elderly volunteers were given B. subtilis supplements for 12 weeks. At the end of the study period, the researchers observed healthy blood values in all healthy participants [31].* It is possible that this may be linked the production of nattokinase by these bacteria once they colonized the digestive tract. 

References

1. Fujita M, Hong K, Ito Y, Misawa S, Takeuchi N, Kariya K, Nishimuro S. Transport of nattokinase across the rat intestinal tract. Biol Pharm Bull. 1995;18(9):1194-1196.
2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol. 1990;84(3):139-143.
3. Sumi H, Hamada H, Tsushima H, et al. A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia. 1987;43:1110-1111.
4. Fujita M, Nomura K, Hong K, et al. Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan. Biochem Biophys Res Commun. 1993;197:1340-1347.
5. Pais E, Alexy T, Holsworth RE Jr, Meise HJ. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc. 2006;35:139-142.
6. Milner M, Makise K. Natto and its active ingredient nattokinase: a potent and safe thrombolytic agent. Alt Comp Therap. 2002;8(3):157-164.
7. Fujita M, Hong K, Ito Y, et al. Thrombolytic effect of nattokinase on a chemically induced thrombosis model in a rat. Biol Pharm Bull. 1995;18:1387-1391.
8. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci. 2003;73:1289-1298.
9. Urano T, Ihara H, Umemura K, et al. The profibrinolytic enzyme subtilisin NAT purified from Bacillus subtilis Cleaves and inactivates plasminogen activator inhibitor type 1. J Biol Chem. 2001;276(27):24690-24696.
10. Hamsten A, de Faire U, Walldius G, et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet. 1987;2:3-9.
11. Wang C, Du M, Zheng D, Kong F, Zu G, Feng Y. Purification and characterization of nattokinase from Bacillus subtilis natto B-12. J Agric Food Chem. 2009;57:9722-9729.
12. Hsia CH, Shen MC, Lin JS, et al. Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects. Nutr Res. 2009;29(3):190-196.
13. Cesarone MR, Belcaro G, Nicolaides AN, et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: The LONFLIT-FLITE randomized, controlled trial. Angiology. 2003;54:531-539.
14. Gong M, Lin HB, Wang Q, Xu JP. Effect of nattokinase on restenosis after percutaneous transluminal angioplasty of the abdominal artery in rabbits. Nan Fang Yi Ke Da Xue Xue Bao. 2008;28(9):1538-1541.
15. Suzuki Y, Kondo K, Ichise, H, et al. Dietary supplementation with fermented soybeans suppresses intimal thickening. Nutrition. 2003;19:261-264.
16. Iwai K, Nakaya N, Kawasaki Y, et al. Antioxidant functions of natto, a kind of fermented soybean: effect on LDL oxidation and lipid metabolism in cholesterol-fed rats. J Agric Food Chem. 2002;50:3597-3601.
17. Yokota T, Hattori T, Ohishi H, et al. The effect of antioxidant-containing fraction from fermented soybean on atherosclerosis development in cholesterol-fed rabbits. Lebensm-Wiss Technol. 1996;29:751-755.
18. Ito H, Suzuki T. Effect of oral administration of nattokinase extract on blood mobility. Society Analytic Bio-Sci. 2002;25(4).
19. Wu D-J, Lin C-S, Lee M-Y. Lipid-lowering effect of nattokinase in patients with primary hypercholesterolemia. Acta Cardiol Sin. 2009;25:26-30.
20. Kim JY, Gum SN, Paik JK, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008;31(8):1583-1588.
21. Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study.
J Nutr. 2004;134:3100-3105.
22. Gast GCM, de Roos NM, Bots ML, et al. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metabol Cardio Dis. 2009;19(7):504-510.
23. Beulens JWJ, Bots ML, Atsma F, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009;203(2):489-493.
24. Schurgers LJ, Spronk HM, Soute BA, Schiffers PM, DeMey JG, Vermeer C. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Blood. 2007;109(7):2823-2831.
25. Brody T. Nutritional Biochemistry, 2nd ed. San Diego: Academic Press; 1999.
26. Paul J, Strickland S, Melchor JP. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med. 2007; 204(8):1999-2008.
27. Merkle DL, Cheng CH, Castellino FJ, Chibber BA. Modulation of fibrin assembly and polymerization by the beta-amyloid of Alzheimer's disease. Blood Coagul Fibrinolysis. 1996;7(6):650-658.
28. Cortes-Canteli M, Paul J, Norris EH, et al. Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease. Neuron. 2010;66(5):695-709.
29. Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2007;4(2):191-197.
30. Hsu RL, Lee KT, Wang JH, Lee LY, Chen RP. Amyloid-degrading ability of nattokinase from Bacillus subtilis natto. J Agric Food Chem. 2009;57(2):503-508.
31. Hong HA, Duc LH, Cutting SM. The use of bacterial spore formers as probiotics. FEMS Microbiol Rev. 2005;29:813-835.
32. Fiaromonti J, Theodoru V, Bueno. Probiotics: what are they? What are their effects on gut physiology. Best Practice Res Clin Gastroenterol. 2003;17:711-724.
33. Hosoi T, Kiuchi K. Natto – a food made by fermenting cooked soybeans with Baccillus subtilis (natto). In: Farnworth ER, ed. Handbook of Fermented Functional Foods. Boca Raton, FL: CRC Press, 2005:227-250.
34. Hosoi T, Kiuchi K. Production and probiotic effects of natto. In Ricca E, Henriques AO, Cutting SM, eds. Bacterial spore formers: probiotics and emerging applications. 2004:143-153.
35. Terada A, Yamamoto M, Yoshimura E. Effect of the fermented soybean product "natto" on the composition and metabolic activity of the human fecal flors. Jpn J Food Microbiol. 1999;16:221-230.
36. Fujisawa T, Shinohara K, Kishimoto Y, Terada A. Effect of miso soup containing Natto on the composition and metabolic activity of the human faecal flora. Microb Ecol Health Dis. 2006;18(2):79-84.
37. Ziemer CJ, Gibson GR. An overview of probiotics, prebiotics and synbiotics in the functional food concept: perspectives and future strategies. Int Dairy J. 1998;8(5-6):473-479.
38. Gibson GR, Roberfroid MB. Dietry modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125(6):1401-1412.
39. Saier MH Jr., Mansour NM. Probiotics and prebiotics in human health. J Mol Microbiol. 2005;10:22-25.



Frequently Asked Questions

What is Nattöbiotic?

Nattöbiotic is the world's first and only RAW Nattokinase Probiotic. Nattöbiotic contains raw natto, including its naturally occurtin antioxidants, vitamin K2, 10 essential amino acids and nattokinase producing probiotic Bacillus Subtillis Natto and and added prebiotic, Isomalto-Oligosacharide.*

How Does Nattöbiotic Work?

Taken on an empty stomach, Nattokinase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Nattokinase supports normal fibrin production within the body; its inherent ability to digest waste particles enables the enzyme to cleanse the cardiovascular system and support healthy circulation.*

Why Should I Take Nattöbiotic?

Anyone that would like to support normal circulatory health naturally should take Nattöbiotic.* The Japanese have benefited from the ancient Natto food for centuries.* All the benefits of Natto can be experienced in a supplement with Nattöbiotic.*

Can I Take Too Much Nattokinase?

Nattöbiotic can safely be incorporated into your supplement regimen.* There have been no indications that one can over-dose from the use of systemic enzymes such as Nattokinase.* However, it is important to follow dosing instructions unless otherwise directed by your healthcare provider.*

Is Nattöbiotic Enteric Coated?

Nattöbiotic is left in its raw form so it is not enteric coated. It has been proven that lymph receptors even in the stomach will absorb Nattokinase, so enteric coating would prevent this.* Not to mention, the traditional Japanes food “Natto” is not enteric coated, so Nattöbiotic isn’t either.*


Supplement Facts

Nattöbiotic

Dehydrated Raw Natto Food in supplement form. Nattobiotic provides all the same benefits of eating the traditional Japanese food Natto.* It contains raw nattokinase, vitamin K2, antioxidants, B.subtilis natto, 10 essential amino acids and prebiotics.*

Nattokinase

A fibrinolytic enzyme that can help to maintain normal blood viscosity and normal cardiovascular health.* Nattokinase can support healthy fibrin concentrations.* It has antioxidant effects that may be beneficial to promote normal prostate health, and aids in the elimination of free radicals.*

B. subtilis Natto

Bacillus Subtilis Natto, a spore form probiotic that inherently produces more nattokinase enzymes which are absorbed into the bloodstream.*

(IMO) Isomalto-Oligosaccharide (prebiotic)

IMO is a natural, certified organic prebiotic fiber, providing low calorie and soluble prebiotic fiber for human digestive health.* IMO is non-GMO, sugar-free and gluten-free. When IMO enters the large intestine, it is fermented by the indigenous bacteria, providing fertilization of beneficial microflora.* It has been clinically shown to greatly increase the number of indigenous bacteria in the digestive tract.* In addition to being Kosher and Halal, our IMO products are FDA GRAS and approved by Health Canada.* Clinical studies have shown IMO to cause the least flatulence in comparison to inulin and FOS.*