Neprinol for Joint Comfort and Health

Because joints like the knees, hips, shoulders and elbows are the areas where bones come together, they perform very important functions in the body. Primarily they allow the skeleton to be flexible for movement. Their structure also ensures that the bones do not come in direct contact with each other. Instead, they are cushioned by cartilage in the joint, synovial membranes around the joint and fluid.

Unfortunately, joint movement becomes more restricted and flexibility decreases with age because of changes in tendons and ligaments. A lifetime of use (and even minor injuries in youth) can also reduce flexibility and the cushioning effect of normal cartilage, allowing bone to rub against bone, resulting in ocassional discomfort and restriction of joint movement. Therefore, the joints require just as much care and maintenance as other parts of the body.

Neprinol, by Arthur Andrew Medical, is a revolutionary blend of systemic enzymes and antioxidants specially formulated to support healthy joint flexibility.* Systemic enzymes are similar to digestive enzymes, but primarily target the bloodstream rather than the gastrointestinal tract. Recent medical breakthroughs have led researchers to use systemic enzymes in people concerned about the health and flexibility of their joints [1-8].* 

Neprinol Helps Support a Normal Inflammatory Response (from over-exertion)*


Over time the surface of the cartilage that cushions the joints can change from smooth to fissured. That's when erosions begin to appear, predisposing the bones that make up the joints to damage. In an attempt to address these changes, immune cells mount a cellular response that involves inflammation. When the inflammatory response is out of balance, joint health may be complicated, in most cases due to changes in the bone and soft tissue in the joint. Therefore, maintaining a normal inflammatory response after exercise may help support joint health and comfort.* 

Recent research shows that supplementation with systemic enzymes may help support a normal inflammatory response in response to exertion [9-13].* Bromelain, a proteolytic (protein-degrading)  pineapple extract, has a number of anti-inflammatory effects in the body; specifically, it has been shown in the laboratory to support normal COX-2, prostaglandin and thromboxane synthesis, normalizing circulating fibrinogen levels, and support healthy cellular adhesion of white blood cells to the sites that require repair [14].* Rutin, a flavonoid (plant pigment) that is hydrolyzed in the gastrointestinal tract to release quercetin [15], and papain, a proteolytic enzyme found in the papaya fruit, have also been shown to support a healthy inflammatory response in both animals and humans [6,16,17].* 

In a blinded study conducted in 2006, German researchers divided 90 patients with degradation of the hip into two groups: half receiving an oral enzyme preparation containing rutin and bromelain, and the other half receiving the anti-inflammatory drug diclofenac. After six weeks, the researchers reported that the enzyme preparation was as effective as diclofenac in standard survey scales of stiffness and physical function, as well as being better tolerated [3].*

These results were supported by another study that compared a standardized enzyme preparation containing both bromelain and rutin with diclofenac. The study reported that the systemic enzyme supplement was as effective as diclofenac in reducing joint tenderness, as well as improving range of motion [8].*

Is Neprinol Safe? 

No serious or adverse side effects have been reported from taking systemic enzymes such as those in Neprinol.* Clinical studies have shown that even extremely large doses of these enzymes are not toxic. If you are taking blood-thinning medication or are pregnant or nursing, you should consult with your physician before taking Neprinol.

* These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure or prevent any disease. For all conditions or illnesses, see a healthcare professional for a full evaluation, diagnosis or treatment plan.


  1. Leipner J, Iten F, Saller R. Therapy with proteolytic enzymes in rheumatic disorders. BioDrugs. 2001;15(12):779-89.
  2. Klein G, Kullich W. Short-term Treatment of Painful Osteoarthritis of the Knee With Oral Enzymes. Clin Drug Invest. 2000;19(1):15-23.
  3. Klein G, Kullich W, Schnitker J, Schwann H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006;24(1):25-30.
  4. Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. 2002;9:681-6.
  5. Wittenborg A, Bock PR, Hanisch J, Saller R, Schneider B. [Comparative epidemiological study in patients with rheumatic diseases illustrated in a example of a treatment with non-steroidal anti- inflammatory drugs versus an oral enzyme combination preparation] [Article in German]. Arzneimittelforschung. 2000;50(8):728-38.
  6. Singer F, Oberleitner H. [Drug therapy of activated arthrosis. On the effectiveness of an enzyme mixture versus diclofenac] [Article in German]. Wien Med Wochenschr. 1996;146(3):55-8.
  7. Tilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess W. Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthritis of the knee joint: an open randomised controlled clinical trial. J Assoc Phys India. 2001;49:621.
  8. Akhtar NM, Naseer R, Farooqi AZ, Wajahat A, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee - a double-blind prospective randomized study. Clin Rheumatol. 2004;23:410-5.
  9. Tassman GC, Zafran JN, Zayon GM. Evaluation of a plant proteolytic enzyme for the control of inflammation and pain. J Dent Med. 1964;19:73-7.
  10. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci. 2001;58:1234-45.
  11. Pirotta F, de Giuli-Morghen C. Bromelain: antiinflammatory and serum fibrinolytic activity after oral administration in the rat. Drugs Exp Clin Res. 1978;4:1-20.
  12. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: A multicentre, doubleblind, randomized trial versus placebo. J Int Med Res. 1990;18:379-88.
  13. Spaeth GL. The effect of bromelains on the inflammatory response caused by cataract extraction: a double-blind study. Eye Ear Nose Throat Mon. 1968;47:634-9.
  14. Yuan G, Wahlqvist ML, He G, Yang M, Li D. Natural products and anti-inflammatory activity. Asia Pac J Clin Nutr. 2006;15(2):143-52.
  15. Erlund I, Kosonen T, Alfthan G, et al. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol. 2000;56:545-53.
  16. Cruz T, Galvez J, Ocete MA, et al. Oral administration of rutoside can ameliorate inflammatory bowel disease in rats. Life Sci. 1998;62:687-95.
  17. Galvez J, Cruz T, Crespo E, et al. Rutoside as mucosal protective in acetic acid-induced rat colitis. Planta Med. 1997;63:409-14.