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Syntol - Shield A Leaky Gut

Probiotics, enzymes, and avoiding certain trigger foods are one of the best ways to stave off a leaky gut.  Leaky gut is a digestive disorder that develops when adjacent epithelial cells in the intestinal tract become weakened or damaged.  Tight layers of epithelial cells form tight junctions, (TJ’s) which are the gatekeeping gaps of the intestinal lining [1]. Weakened epithelial junctions allow toxins, undigested food, or harmful microorganisms such as candida (yeast) to leak through the intestinal wall and enter the bloodstream [1, 2]. Tight junctions are small gaps in the wall of the intestines that allow proper nutrient transfer, while preventing undesirable compounds from passing through the intestinal tract into the blood.

The development of leaky gut is associated with various factors that include candida (yeast) or bacterial overgrowth in the gut, eating inflammatory or gut-irritating foods, and taking certain medications [1, 2]. Two of the main irritants are invader overgrowth and gluten intake because they heighten the production of a protein called zonulin. Tight junctions gradually begin to loosen as zonulin levels increase. This causes harmful particles to pass into the bloodstream where they can cause an overactive immune response and lead to intestinal discomfort [3, 4]. The accumulation of foreign invaders in the bloodstream due to a leaky gut can also cause inflammatory issues as well as bloating, cramps, gas, food sensitivities, and other digestive problems [2].

The Benefits of Syntol AMD

Syntol AMD is a powerful dietary supplement formulated with probiotics, prebioitics, and enzymes that support the health of the intestinal lining by populating the gut with beneficial bacterial strains and disrupting invader (e.g., yeast) overgrowth. Yeast overgrowth, a problem linked to a weakened immune system, taking antibiotics, and consuming excess amounts of sugar or processed foods, is a common trigger of leaky gut [5].

Candida yeast typically co-exist in the gut with other healthy bacteria, but yeast overgrowth causes these microorganisms to shift into a fungal form that can quickly spread throughout the gut and even compromise immune cells. This makes it harder for the immune system to restore and maintain health [2]. The fungal state is particularly problematic because these microorganisms produce long, root-like structures called candida rhizoids that allow them to attach to and penetrate the intestinal lining. The penetration can gradually damage the walls of the intestines, leading to a leaky gut that allows toxins to enter the bloodstream [6]. Syntol was specifically designed to target yeast overgrowth.

In particular, this beneficial supplement is categorized as a synbiotic (pre+pro) with yeast cleanse that combines prebiotic, probiotic, and yeast targeting enzymes. It contains eight different strains of probiotics that total around 13.6 billion good bacteria per serving:

  • Bacillus subtilis
  • Lactobacillus helveticus
  • Saccharomyces boulardii
  • Lactobacillus acidophilus
  • Lactobacillus rhamnosus
  • Lactobacillus plantarum
  • Lactobacillus lactis
  • Bifidobacterium bifidum

Lactobacillus and Bifidobacterium strains are well-known for their resistance to digestion as well as their ability to become established in the gut when taken orally [7]. Additionally, strains such as L. rhamnosus, L. plantarum, L. acidophilus, and L. helveticus enhance the health of intestinal lining cells [8-12]. Furthermore, B. subtilisis is a spore-forming strain that is well-suited for survival in the gut, while S. boulardii is a beneficial yeast that helps limit the growth of other harmful yeasts [13].

These different bacterial and yeast strains do not interfere with each other, thereby allowing each organism to yield the best possible benefits. Furthermore, the prebiotic IMO (isomalto-oligosaccharide) in Syntol AMD maximizes the potential for probiotics to flourish in the gut [14]. IMO is a form of fiber that supports the growth of good bacteria, particularly Bifidobacterium and Lactobacillus strains [15], and fiber also helps clear waste from the intestinal tract [16]. This lowers gut leakiness and irritation of the intestinal lining.

In addition to populating the gut with beneficial bacteria, Syntol AMD also contains a blend of enzymes that target harmful invaders, particularly candida yeast overgrowth, in the gut. First, the enzymes digest the protective outer layer that surrounds the yeast and then they destroy the cells’ inner components. Then the enzymes clear away the debris and toxins released by dead yeasts before they can trigger any additional immune responses.

Bacterial Pathogens Probiotics

Overall, the scientifically-formulated blend in Syntol AMD:

  • Enhances digestion
  • Adds intestinal microflora balance
  • Protects the intestines from leaking into the immune system
  • Heightens resistance to various health issues
  • Hinders the growth of harmful microorganisms linked to a leaky gut

This powerful formula supports an optimal intestinal environment for healthy bacterial growth and enzymes that boost the clearance of harmful yeast, bacteria, and toxins from the body. Syntol AMD promotes a strong gut barrier that enhances overall health.

References

  1. Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29(6):902-10.
  2. Odenwald MA, Turner JR. Intestinal permeability defects: is it time to treat? Clin Gastroenterol Hepatol. 2013;11(9):1075-1083.
  3. Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol. 2012;10(10):1096-100.
  4. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011; 91(1):151-75.
  5. Martin Lopez JE. Candidiasis (vulvovaginal). BMJ Clin Evid, 2015:0815.
  6. Lamps LW, et al. Fungal Infections of the Gastrointestinal Tract in the Immunocompromised Host-An Update. Adv Anat Pathol. 2014;21(4):217-227.
  7. Marteau P, Shanahhan F. Basic aspect and pharmacology of probiotics: an overview of pharmacokinetics, mechanisms of action and side-effects. Best Practice Res Clin Gastroenterol. 2003;17:725-740.
  8. Miyauchi E, Morita H, Tanabe S. Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo.J Dairy Sci. 2009;92(6):2400-8
  9. Liu ZH, Shen TY, Zhang P, Ma YL, Moyer MP, Qin HL. Protective effects of Lactobacillus plantarum against epithelial barrier dysfunction of human colon cell line NCM460. World J Gastroenterol. 2010;16(45):5759-65.
  10. Montalto M, Maggiano N, Ricci R, Curigliano V, Santoro L, Di Nicuolo F, Vecchio FM, Gasbarrini A, Gasbarrini G. Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells.Digestion. 2004;69(4):225-8.
  11. Zareie M, Johnson-Henry K, Jury J, Yang PC, Ngan BY, McKay DM, Soderholm JD, Perdue MH, Sherman PM. Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress.Gut. 2006;55(11):1553-60.
  12. Karczewski J, Troost FJ, Konings I, Dekker J, Kleerebezem M, Brummer RJ, Wells JM. Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier.Am J Physiol Gastrointest Liver Physiol. 2010;298(6):G851-9.
  13. McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World J Gastroenterol. 2010;16(18):2202-22.
  14. Gu Q, Yang Y, Jiang G, Chang G. Study on the regulative effect of isomaltooligosaccharides on human intestinal flora. Wei Sheng Yan Jiu. 2003;32(1):54-55.
  15. Rycroft CE, Jones MR, Gibson GR, Rastall RA. A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides. J Appl Microbiol. 2001;91(5):878 887.
  16. Gibson GR, Roberfroid MB. Dietary manipulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125:1401-1479.