Living Past 100 Years Old What Does The Science Tell Us?

Swedish Study on Longevity: Unraveling the Biomarker Mysteries of Centenarians

Introduction to the Swedish AMORIS Cohort Study The quest for understanding the secrets of longevity has been a long-standing fascination for scientists and researchers worldwide. The Swedish AMORIS cohort study stands as a testament to this pursuit, aiming to unlock the mysteries of exceptional longevity by examining the blood biomarkers of centenarians. These individuals, who have surpassed the age of 100, offer a unique window into the intricacies of aging and the factors that contribute to a long, healthy life.

Background and Scope of the Study The Swedish AMORIS cohort embarked on this ambitious project, meticulously analyzing and comparing the blood biomarker profiles of centenarians to those of their shorter-lived peers. Spanning an impressive 35 years, the study tracked its participants, revealing that out of a vast pool of participants, 1,224 individuals reached the remarkable milestone of their 100th birthday. The gender distribution among these centenarians was particularly noteworthy, with 84.6% being female, suggesting potential gender-related factors in longevity.

The Cholesterol Conundrum Among the myriad of findings, one that stood out was the elevated levels of total cholesterol among centenarians. This challenges the widely accepted belief that high cholesterol is predominantly a risk factor for heart diseases. The study suggests that, for some individuals, higher cholesterol levels might not be detrimental and could even be linked to longevity. This revelation prompts a reevaluation of our understanding of cholesterol and its intricate relationship with aging.

Decoding the Biomarkers: A Detailed Analysis The study's primary focus was on a plethora of biomarkers associated with various health aspects. Each biomarker offers a unique insight, potentially revealing the secrets to living past 100.

  1. Iron Levels: Another unexpected discovery was the elevated iron levels in centenarians. While iron is undeniably essential for various bodily functions, excessive amounts can lead to oxidative stress, potentially damaging cells. The findings suggest that centenarians might possess unique mechanisms to regulate iron, striking a balance between its benefits and potential harms.

  2. Glucose and Metabolic Health: Centenarians exhibited lower glucose levels, emphasizing the significance of maintaining stable blood sugar levels throughout life. Stable glucose levels are often associated with a reduced risk of diabetes and other metabolic disorders, highlighting the importance of dietary and lifestyle choices in longevity.

  3. Kidney Function and Creatinine Levels: The study found that centenarians had lower creatinine levels, indicating efficient kidney function and possibly a slower rate of renal aging. Kidney health plays a pivotal role in overall well-being, and these findings underscore its importance in the context of longevity.

  4. Liver Health: Centenarians displayed lower levels of several liver enzymes, suggesting healthier liver function and metabolism. The liver, being a vital organ for detoxification and metabolism, might play a more significant role in longevity than previously thought.

Lifestyle and Environmental Factors While genetics undoubtedly play a role in longevity, environmental and lifestyle factors cannot be ignored. The study prompts questions about the diets, physical activity levels, mental health, and social connections of centenarians. Did they follow specific dietary patterns? Were they more active than their peers? These are areas ripe for further exploration.

Homogeneity in Biomarker Profiles The consistent biomarker profiles among centenarians, even at age 65, hint at both genetic predispositions and modifiable lifestyle factors contributing to exceptional longevity. This consistency suggests that certain factors, if identified and acted upon early, could influence one's chances of living a longer life.

Implications for the Future of Aging Research The findings from the Swedish AMORIS cohort study are groundbreaking. They pave the way for personalized healthcare approaches, where interventions and lifestyle recommendations are tailored based on individual biomarker profiles. This could revolutionize the way we approach aging, moving from a one-size-fits-all approach to a more individualized strategy.

Conclusion: The Road Ahead The Swedish AMORIS cohort study, with its in-depth exploration of centenarian blood biomarkers, provides invaluable insights into the realm of longevity. The elevated cholesterol levels among centenarians, juxtaposed with their extended lifespan, challenges our conventional wisdom surrounding cholesterol and heart health. As aging research continues to evolve, studies like these lay the groundwork for innovative strategies aimed at promoting healthy aging and potentially extending human lifespans. The journey to understanding longevity is ongoing, but with each discovery, we move closer to the ultimate goal: a long, healthy, and fulfilling life for all.

Further Studies and Recommendations The findings from this study open doors for further research. It would be beneficial to explore the lifestyles of centenarians in more detail, delving into their diets, exercise routines, mental health practices, and social connections. Additionally, understanding the role of modern medicine, vaccinations, and other healthcare interventions in their longevity could provide further insights. The quest for longevity is a multifaceted one, and the Swedish AMORIS cohort study is a significant step in the right direction.


  • Murata, S., Ebeling, M., Meyer, A. C., Schmidt-Mende, K., Hammar, N., & Modig, K. (2023). Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort. GeroScience, 1-11. doi:10.1007/s11357-023-00936-w.